Psychiatric disorders in adolescent and young adult patients with phenylketonuria
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- 作者：Filippo Mantia ; 1 ; filippo.manti@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Francesca Nardecchiaa ; b ; 1 ; francesca.nardecchia@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Flavia Chiarottic ; flavia.chiarotti@iss.it" class="auth_mail" title="E-mail the corresponding author ; Claudia Carduccid ; claudia.carducci@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Carla Carduccid ; Vincenzo Leuzzia ; vincenzo.leuzzi@uniroma1.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：ETPKU ; early treated phenylketonuria ; IQ ; intelligence quotient ; Phe ; phenylalanine ; WAIS-R ; Wechsler Adult Intelligence Scale-Revised ; IDC ; Index of Dietary Control
- 刊名：Molecular Genetics and Metabolism
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：117
- 期：1
- 页码：12-18
- 全文大小：262 K
文摘
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17 out of 46 ETPKU (37%) patients suffer from psychiatric disorders.
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25 out of 46 ETPKU (54%) patients showed clinical scores on at least one scale of the psychiatric questionnaires.
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Anxiety and withdrawal are the most frequent self-reported symptoms.
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The burden of the disease might act as psychological stress for children and their families.
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The occurrence of psychiatric symptoms is not associated with quality of metabolic control.