A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area

详细信息    查看全文

• 作者：Denggui Wen ; Baoen Shan ; Shijie Wang ; Liwei Zhang ; Lizhen Wei ; Wendi Zhou ; Qing Peng
• 关键词：GCA ; ESCC ; Familial cancer ; Sporadic cancer ; Age at onset ; Synchronous primary carcinoma
• 刊名：European Journal of Medical Genetics
• 出版年：2010
• 出版时间：September-October 2010
• 年：2010
• 卷：53
• 期：5
• 页码：250-255
• 全文大小：135 K

文摘

Background

To find a genetic component in gastric cardia adenocarcinomas (GCA).

Methods

Age at onset (AO) and rate of another synchronous primary upper gastrointestinal carcinoma (RASPUGIC) were compared among the three GCA groups with positive (N = 766), negative (N = 2167), and missing family history of upper gastrointestinal cancer (FHUGIC) (N = 198). These 3131 GCAs were diagnosed on 3128 primary GCA patients of a consecutive surgical cohort treated from 1973 through 1994 at the Department of Thoracic Surgery in the 4th Hospital of Hebei Medical University in a high-risk region in northern China.

Results

Overall, GCAs of positive FHUGIC showed a significantly younger AO and a significantly higher RASPUGIC than the negative group (54.68 ± 7.35 vs 55.94 ± 7.47 years old, Pt-test = 0.000; 3.1 % vs 1.3 % , χ2 = 11.02, P = 0.001). The difference in AO and RASPUGIC between the positive and the negative FHUGIC GCAs is significant or nearly significant in most subgroups; minimizing the possibility of a false association due to bias or confounding (e.g. significant stage-specific differences in AO between familial and sporadic GCAs observed in the subgroup of T2,3N0M0 (P = 0.000) and T2,3,4N1M0 (P = 0.03) exclude the possibility of ascertainment bias towards an earlier diagnosis in familial cases), and the association between FHUGIC and RASPUGIC is statistically significant for GCAs of younger AO (<55 yr old, RASPUGIC 3.8 % vs 1.6 % vs 1.1 % for the positive, negative and missing FHUGIC GCAs respectively, χ2 = 6.50, P = 0.04), but not significant for the later onset GCAs (≥55 yr old, RASPUGIC 2.5 % , 1.1 % , 1.9 % for the positive, negative and missing FHUGIC respectively, χ2 = 4.22, P = 0.12).

Conclusion

These findings suggest a genetic component in GCA in the Chinese high-risk region, and genetic predisposition may determine the age at onset and number of primary upper gastrointestinal cancer.