Self-templated formation of aptamer-functionalized copper oxide nanorods with intrinsic peroxidase catalytic activity for protein and tumor cell detection
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- 作者：Chien-Wei WuaAuthor Vitae ; Scott G. HarrounbAuthor Vitae ; Chia-Wen LiencAuthor Vitae ; Huan-Tsung ChangcAuthor Vitae ; Binesh UnnikrishnanaAuthor Vitae ; Irving Po-Jung LaiaAuthor Vitae ; Jia-Yaw ChangdAuthor Vitae ; Chih-Ching Huanga ; e ; f ; huanging@ntou.edu.tw" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Copper oxide nanoparticles ; Enzyme ; Aptamers ; Proteins ; Tumor cells
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：227
- 期：Complete
- 页码：100-107
- 全文大小：1617 K
文摘
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Aptamer-functionalized copper nanoparticles (Apt-Cu NPs) readily oxidized to Apt-CuO/Cu2O NPs.
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Apt−CuO/Cu2O NPs exhibited strong peroxidase-like activity.
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Catalytic activity of the nanoparticles was significantly suppressed by thrombin.
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Detection of breast tumor cells using Mucin1 aptamer-templated CuO/Cu2O NPs.