Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stress
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- 作者：Ruili Danga ; b ; 1 ; Hualin Caib ; 1 ; Ling Zhanga ; Donglou Lianga ; Chuanfeng Lva ; Yujin Guoa ; gyj99@126.com" class="auth_mail" title="E-mail the corresponding author ; Ranyao Yanga ; Yungui Zhub ; Pei Jianga ; jiangpeicsu@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuregulin-1/ErbB signaling ; Depression ; Chronic unpredictable mild stress ; Sertraline
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：145-150
- 全文大小：746 K
文摘
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Chronic stress exposure induced depression-like behaviors in rats.
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Chronic stress exposure altered NRG1/ErbB signaling in rat brain.
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The stressed rats exhibited the synchronous compromise of ERK and Akt activation.
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Sertraline treatment restored dysregulated NRG1/ErbB signaling in stressed rats.