Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress
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- 作者：Vineet Mehta vineet.mehta20@gmail.com ; Arun Parashar arunnittyparashar@gmail.com ; Malairaman Udayabanu ; m_udayabanu@rediffmail.com
- 关键词：Quercetin ; Stress ; Anxiety ; Depression ; Cognition ; Antioxidant
- 刊名：Physiology & Behavior
- 出版年：2017
- 出版时间：15 March 2017
- 年：2017
- 卷：171
- 期：Complete
- 页码：69-78
- 全文大小：1375 K
- 卷排序：171
文摘
Chronic unpredicted stress induced anxiety, depression and cognitive deficit in mice. Stress elevated oxidative and inflammatory stress markers in hippocampus. Chronic quercetin treatment reversed behavioral dysfunction. Quercetin attenuated hippocampal oxidative stress and lowered pro-inflammatory cytokine expression. Quercetin rescued hippocampal neurons from stress induced damage.