Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex
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- 作者：Ermelinda Lomazzo ; 1 ; lomazzo@uni-mainz.de ; Florian Kö ; nig1 ; Leila Abassi ; Ruth Jelinek ; Beat Lutz
- 关键词：Chronic unpredictable stress ; Epigenetics ; Neuropeptide-Y ; Endocannabinoids ; URB597
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：113
- 期：part_PA
- 页码：301-313
- 全文大小：1782 K
- 卷排序：113
文摘
Chronic stress induces epigenetic modifications in Npy and CB1 genes. Chronic stress alters Npy expression and Npy1r function in the cingulate cortex. Chronic stress alters CB1 mRNA in low CB1-expressing neurons. Reduced H3K9ac level may be responsible for impairments at molecular level. URB597 prevents the altered H3K9ac levels at the Npy gene.