New asymmetric Schiff base ligand derived from allylamine and 2,3-dihydroxybenzaldehyde and its molybdenum(VI) complex: Synthesis, characterization, crystal structures, computational studies and antibacterial activity together with synergistic effect against Pseudomonas aeroginosa PTTC 1570

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• 作者：Hadi Amiri Rudbari^a ; ^{h.a.rudbari@sci.ui.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; ^{hamiri1358@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mahsa Khorshidifard^a ; Banafshe Askari^a ; Neda Habibi^b ; Giuseppe Bruno^c
• 关键词：Schiff base ; Crystal structure ; Mo(VI) complex ; Pseudo-scorpionate Ligand ; Antibacterial activity
• 刊名：Polyhedron
• 出版年：2015
• 出版时间：4 November 2015
• 年：2015
• 卷：100
• 期：Complete
• 页码：180-191
• 全文大小：2391 K

文摘

A new unsymmetrical Schiff base ligand (H₂L) was derived from the 1:1 M condensation of 2,3-dihydroxybenzaldehyde with allylamine. Molybdenum(VI) complex, MoO₂L₂, was synthesized from the reaction of MoO₂(acac)₂ with the Schiff base ligand in a 1:2 ratio in methanol at ambient temperature. The Schiff base ligand and its Mo(VI) complex were characterized by elemental analyses, FT-IR, ¹H NMR, ¹³C NMR and UV–Vis spectroscopies and single crystal X-ray analysis. The molecular structure of schiff base ligand and Mo(VI) complex showed pseudo-scorpionate structure in solid state. The MoO₂L₂ complex adopts an octahedral environment around the Mo center with a cis-oxo configuration. The other coordination sites are occupied by the hydroxyl oxygen atoms of the two Schiff base ligands. The pseudo-scorpionate interaction in ligand was investigated by theoretical calculation. The Schiff base ligand and its Mo(VI) complex were also tested for their in vitro antimicrobial activity against Staphylococcus aureus (ATCC 29737) and Pseudomonas aeroginosa (PTTC 1570) as examples of Gram-positive and Gram-negative bacterial strains, respectively, by disc diffusion method. The results indicated that the Schiff base ligand had a better antibacterial activity than its Mo(VI) complex and surprisingly, they were synergistic when used against P. aeroginosa PTTC 1570.