Effects of GRASP variation on memory in psychiatrically healthy individuals and cognitive dysfunction in schizophrenics

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• 作者：Natalie Matosin^a ; ^b ; ^c ; ^d ; Melissa J. Green^a ; ^c ; ^f ; Kelly A. Newell^a ; ^b ; Francesca Fernandez-Enright^a ; ^b ; ^e ; ^{francesca.fernandez@acu.edu.au}
• 关键词：GRASP ; general receptor for phosphoinositides-1-associated scaffold protein ; SNP ; single nucleotide polymorphism ; CD ; cognitive deficits ; CS ; cognitively spared ; PSD ; postsynaptic density ; NMDARs ; N-methyl-d-aspartate receptors ; AMPARs ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors ; GABA ; gamma aminobutyric acid ; mGluR1/5 ; metabotropic glutamate receptors 1 and 5 ; ECS ; electroconvulsive shock therapy ; 5&prime ; UTR ; 5&prime ; untranslated region ; DIP ; diagnostic interview for psyc
• 刊名：Gene Reports
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：6
• 期：Complete
• 页码：121-127
• 全文大小：413 K
• 卷排序：6

文摘

We explored the effects of rs10876227 in GRASP on cognition and in schizophrenia. Rs10876227 effected immediate, working and delayed memory in healthy controls. Rs10876227 was associated with worse cognitive dysfunction in men with schizophrenia. Rs10876227 did not affect GRASP protein expression in the CA1 region.