Ptc7p Dephosphorylates Select Mitochondrial Proteins to Enhance Metabolic Function

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• 作者：Xiao Guoup>1up>up> ; up>up>2up>up> ; up>up>6up> ; Natalie M. Niemiup>1up>up> ; up>up>3up>up> ; up>up>6up> ; Paul D. Hutchinsup>2up>up> ; up>up>4up> ; Samson G.F. Condonup>3up> ; Adam Jochemup>1up> ; Arne Ulbrichup>2up>up> ; up>up>4up> ; Alan J. Higbeeup>2up>up> ; up>up>4up> ; Jason D. Russellup>1up>up> ; up>up>4up> ; Alessandro Senesup>3up> ; Joshua J. Coonup>1up>up> ; up>up>2up>up> ; up>up>4up>up> ; up>up>5up> ; David J. Pagliariniup>1up>up> ; up>up>3up>up> ; up>up>7up>up> ; up>up>dpagliarini@morgridge.orgup>
• 关键词：Ptc7 ; Pptc7 ; mitochondria ; phosphatase ; phosphoproteomics ; mitochondrial phosphorylation ; citrate synthase
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：307-313
• 全文大小：1391 K
• 卷排序：18

文摘

Ptc7p is an active, conserved PP2C-type mitochondrial matrix phosphatase Loss of Ptc7p causes respiratory defects and enhanced select matrix phosphorylation Cit1p is a Ptc7p target whose activity is diminished by phosphorylation Dephosphorylation reactivates Cit1p likely by enabling its requisite dimerization