Use of fibrin glue in preventing urethrocutaneous fistula after hypospadias repair

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• 作者：Saroj C. Gopal ; Ajay N. Gangopadhyay ; T. Vittal Mohan ; Vijai D. Upadhyaya ; An ; P ; ey ; Ashish Upadhyaya ; Dinesh K. Gupta
• 关键词：Fibrin glue ; Hypospadias ; Proximal penile ; Single stage
• 刊名：Journal of Pediatric Surgery
• 出版年：2008
• 出版时间：October 2008
• 年：2008
• 卷：43
• 期：10
• 页码：1869-1872
• 全文大小：389 K

文摘

Urethrocutaneous fistula is one of the most common complications after hypospadias surgery.

The incidence of fistula development has varied from 4 % to 20 % in larger series. We sought to investigate the role of fibrin glue (Tisseel manufactured by Baxter India Pvt Ltd, Chennai, India) to reduce the chances of fistula formation in cases in proximal penile hypospadias.

Method

A total of 120 patients with proximal penile hypospadias (patients having urethral meatus at posterior third of penile shaft and at penoscrotal junction) were included in the present study. Patients were randomly allocated into 2 groups of 60 each by using Strata 9 software random number table. In group A, fibrin glue was used as a sealant after hypospadias surgery, whereas in group B, no sealant was used. All the operations were performed by single surgeon using transverse preputial tubularized island flap urethroplasty.

Result

Fistula formation occurred in 6 cases in group A (10 % ) and 19 cases in group B (32 % ) (P = .027). The fistulae observed in fibrin glue group A were single and small in size (<1 mm). Multiple (≥2 fistulae) and larger fistulae (>2 mm) were observed in group B. Overall complication was significantly higher in group B (P = .006).

Conclusion

Fibrin glue in hypospadias repair does not eliminate fistula formation. However, it seems that it minimizes the incidence of fistula formation.