Effect of aerobic exercise on insulin resistance and central adiposity disappeared after the discontinuation of intervention in overweight women

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• 作者：Shenglong Le^a ; Lijuan Mao^b ; ^{maolijuan@sus.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Dajiang Lu^c ; ^{ludajiang2000@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Yifan Yang^a ; Xiao Tan^d ; Petri Wiklund^d ; Sulin Cheng^a ; ^c
• 关键词：Exercise intervention ; Obesity ; Postmenopause ; Premenopause ; Relapse
• 刊名：Journal of Sport and Health Science
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：5
• 期：2
• 页码：166-170
• 全文大小：592 K

文摘

This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance (HOMA-IR) are maintained after discontinuation of intervention in the overweight/obese (OWOB) women.

Methods

The study subjects were from 2 independent studies with similar aerobic exercise (AE) intervention programs. In study I, 15 OWOB postmenopausal women with pre-diabetes (body mass index, BMI = 24–33 kg/m², aged 52–65 years) completed an 8-month exercise intervention and were followed for 2 years after the intervention. In study II, 12 OWOB (BMI = 25–35 kg/m², aged 30–50 years) premenopausal women participated in a 6-week AE and were followed for 4 years after the intervention. The exercise program consisted of progressive AE with intensity of 60%–75% of initial fitness level, 30–60 min/time and 3–5 times/week. Fat mass (FM) was assessed by Dual Energy X-ray Absorptiometry (DXA Prodigy; study I) or bioelectrical impedance device (Inbody 720; study II). Plasma glucose and insulin were assessed by chemiluminescent immunoassay and HOMA-IR was calculated.

Results

Both 8-month and 6-week moderate AE were effective in reducing HOMA-IR (−18.9%, p = 0.012 and −26.7%, p = 0.046, respectively), and 8-month AE reduced FM at upper abdominal region (−6.2%, p = 0.021). However, these improvements were not maintained in either study at the follow-up.

Conclusion

The AE program used in these studies was effective to reduce insulin resistance and/or FM in central body region among overweight and obese women. However, when exercise intervention was discontinued, the beneficial effects following both short- and long-term intervention disappeared. Thus maintaining exercise seems to be required if one wants to reap the benefits of exercise in the long-term.