FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1

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• 作者：Toru Fukuda ; Kazuhiro Kanomata ; Junya Nojima ; Itaru Urakawa ; Tetsuo Suzawa ; Mana Imada ; Akiko Kukita ; Ryutaro Kamijo ; Takeyoshi Yamashita ; Takenobu Katagiri
• 关键词：FGF23 ; Egr-1 ; NAB2 ; Co-repressor ; Transcription
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2007
• 出版时间：2 February 2007
• 年：2007
• 卷：353
• 期：1
• 页码：147-151
• 全文大小：368 K

文摘

Fibroblast growth factor 23 (FGF23) is a key humoral factor in phosphate homeostasis and skeletogenesis, though the nature of its intracellular signaling is still unclear. Recently, Egr-1, a zinc-finger transcription factor, was identified as an immediate early response gene of FGF23 in the kidney. We report here, that FGF23 induces not only Egr-1 but also two isoforms of NAB2, which are specific co-repressors of Egr-1. Both isoforms of NAB2 induced by FGF23 were localized in the nucleus and suppressed the transcriptional activity of Egr-1. A negative feedback loop established by Egr-1 and NAB2 may thus be involved in mediating the physiological effects of FGF23.