Sampling on ice will not yield reliable uric acid monitoring in rasburicase-treated patients

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• 作者：Barbara Depreter^a ; ^c ; Veronique Stove^a ; ^b ; Joris Delanghe^a ; ^b ; ^{joris.delanghe@ugent.be}
• 关键词：TLS ; tumour lysis syndrome ; UA ; uric acid ; pKa ; acid dissociation constant ; EMA ; European Medicines Agency ; FDA ; Food and Drug Administration ; min ; minutes ; h ; hour ; RT ; room temperature ; LOD ; limit of detection ; PCCC ; PreciControl ClinChem ; Km ; Michaelis&ndash ; Menten constant ; Eact ; activation energy ; R2 ; correlation coefficient ; V ; uricolytic activity ; Vmax ; maximum uricolytic activity ; S ; UA concentration ; CI ; confidence interval
• 刊名：Clinical Biochemistry
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：49
• 期：18
• 页码：1390-1395
• 全文大小：581 K
• 卷排序：49

文摘

Serum cooling will not arrest uricolysis in the presence of rasburicase. Routinely monitored rasburicase-treated patients present with negative UA concentrations. Rasburicase's uricolytic capacity knows a modest logarithmic decrease of 4–5% per − 1 °C.