Conflict of Interest in the Assessment of Hyaluronic Acid Injections for Osteoarthritis of the Knee: An Updated Systematic Review

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• 作者：Jonathon O. Printz ; John J. Lee ; Michael Knesek ; Andrew G. Urquhart
• 关键词：hyaluronic acid injections ; knee osteoarthritis ; systematic review
• 刊名：The Journal of Arthroplasty
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：28
• 期：8_supp_S
• 页码：30-33.e1
• 全文大小：351 K

文摘

The search results of a recent systematic review of prospective, randomized, placebo-controlled trials on hyaluronic acid injections for knee arthritis were updated and reviewed for funding source and qualitative conclusions. Forty-eight studies were identified; 30 (62.5 % ) were industry funded, and 3 (6.25 % ) were not. Fifteen (31.3 % ) studies did not identify a funding source. An association was observed between a reported potential financial conflict of interest of the author and the qualitative conclusion (P = 0.018). None of the studies with a reported financial conflict of interest of at least one author had an unfavorable conclusion; 11 (35 % ) of the 31 studies with no industry-affiliated authors indicated that hyaluronic acid injection for knee osteoarthritis was no more effective than a placebo injection.