MDG-1, an Ophiopogon polysaccharide, alleviates hyperlipidemia in mice based on metabolic profile of bile acids
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- 作者：Linlin Shia ; Jie Wangb ; Yuan Wanga ; amoness@163.com" class="auth_mail" title="E-mail the corresponding author ; Yi Fenga ; fyi_shutcm@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：FXR ; farnesoid X receptor ; LXR ; liver X receptor ; NAFLD ; nonalcoholic fatty liver disease ; FOS ; fructooligosaccharides ; DIO ; diet-induce obese ; UPLC&ndash ; MS ; ultra-performance liquid chromatography mass-spectrometry ; CA ; cholic acid ; CDCA ; chenodeoxycholic acid ; DCA ; deoxycholic acid ; UDCA ; ursodeoxycholic acid ; LCA ; lithocholic acid ; HDCA ; hyodeoxycholic acid ; TCA ; taurocholic acid ; GCA ; glychocholic acid ; TCDCA ; taurochenodeoxycholic acid ; TDCA ; taurodeoxycholic acid ; GDCA ; glychodeoxycholic
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：5 October 2016
- 年：2016
- 卷：150
- 期：Complete
- 页码：74-81
- 全文大小：2425 K
文摘
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MDG-1 lowers TC contents in obese mice via affecting bile acids metabolic profile.
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The lipid-control effect of MDG-1 is mediated by promoting cholesterol catabolism.
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MDG-1 affects gene expression related to the negative feedback control of bile acids.