Alkylphloroglucinol derivatives and triterpenoids with soluble epoxide hydrolase inhibitory activity from Callistemon citrinus

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• 作者：Pham Ngoc Khanh^a ; Ho Viet Duc^b ; Tran Thu Huong^a ; Ninh The Son^a ; Vu Thi Ha^a ; Doan Thi Van^a ; Bui Huu Tai^c ; Ji Eun Kim^c ; Ah Reum Jo^c ; Young Ho Kim^c ; ^{yhk@cnu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Nguyen Manh Cuong^a ; ^{nmcuong_inpc@yahoo.com.vn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：gallomyrtucommulone A (PubChem CID ; 11505110) ; endoperoxide G3 (PubChem CID ; 11207902) ; betulinic acid (PubChem CID ; 64971) ; diospyrolide (PubChem CID ; 3037455) ; ursolic acid (PubChem CID ; 64945)
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：39-44
• 全文大小：559 K

文摘

Phytochemical analysis of the leaves and stems of Callistemon citrinus (Curtis) Skeels led to the isolation of two new alkylphloroglucinols, gallomyrtucommulone E and F (1 and 2), along with four other known alkylphloroglucinol derivatives, gallomyrtucommulone A (3), endoperoxide G3 (4), myrtucommulone B (5), callistenone B (6) and five known triterpenoids, including betulinic acid (7), 3β-acetylmorolic acid (8), 3β-hydroxy-urs-11-en-13(28)-olide (9), diospyrolide (10) and ursolic acid (11). The structures of the natural compounds were determined from the spectroscopic evidences including 1D-/2D-NMR and HR-MS spectrometry. All the isolated compounds were assessed for the effects on the sEH inhibitory activity. The acylphloroglucinols myrtucommulone B (5)/callistenone B (6) (in mixture), and two triterpenoids, ursolic acid (11) and 3β-hydroxy-urs-11-en-13(28)-olide (9) displayed strong inhibition of sEH activity, with IC₅₀ values of 0.7, 11.2 and 24.8 μM, respectively.