Structural Insights into Nonspecific Binding of DNA by TrmBL2, an Archaeal Chromatin Protein
详细信息 查看全文
- 作者：Misbha Ud Din Ahmad1 ; Ingrid Waege2 ; Winfried Hausner2 ; Michael Thomm2 ; Winfried Boos1 ; Kay Diederichs1 ; Wolfram Welte1 ; wolfram.welte@uni-konstanz.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ewHTH ; extended winged helix&ndash ; turn&ndash ; helix ; wHTH ; winged helix&ndash ; turn&ndash ; helix ; dsDNA ; double-stranded DNA ; NCS ; noncrystallographic symmetry ; HTH ; helix&ndash ; turn&ndash ; helix
- 刊名：Journal of Molecular Biology
- 出版年：2015
- 出版时间：9 October 2015
- 年：2015
- 卷：427
- 期：20
- 页码：3216-3229
- 全文大小：3032 K
文摘
- m" id="list_l0005">
- •
The structure of an archaeal DNA binding protein alone and in complex with dsDNA.
- •
The tetrameric protein shows an as yet unknown dsDNA binding mode.
- •
The crystal structure shows a superposition of three mutually shifted copies of the bound DNA.
- •
Compared to other HTH repressor proteins, polar interactions seem to be eluded.