Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators

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• 作者：Nicole St-Denis¹ ; Gagan D. Gupta¹ ; Zhen Yuan Lin¹ ; Beatriz Gonzalez-Badillo¹ ; ³ ; Amanda O. Veri² ; James D.R. Knight¹ ; Dushyandi Rajendran¹ ; Amber L. Couzens¹ ; Ko W. Currie² ; Johnny M. Tkach¹ ; Sally W.T. Cheung¹ ; Laurence Pelletier¹ ; ² ; ^{pelletier@lunenfeld.ca} ; Anne-Claude Gingras¹ ; ² ; ⁴ ; ^{gingras@lunenfeld.ca}
• 关键词：phosphatase ; proteomics ; interactome ; mitosis ; phosphorylation ; CDC14A ; DUSP19 ; PTPRF ; DUSP23 ; PLK4
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2488-2501
• 全文大小：5262 K
• 卷排序：17

文摘

The phosphatase interactome contains 1,335 interactions made by 140 phosphatases Mitosis requires phosphatases of all evolutionary lineages, including several PTPs PTPs play diverse roles in mitosis, notably in adhesion and centriole biogenesis Combining complementary screens provides testable hypotheses about protein function