In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries
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- 作者：Doshi Utkarsh ; Carol Loretz ; Albert P. Li ; lialbert@invitroadmet.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatotoxicity ; DILI ; Idiosyncratic hepatotoxicity ; Individual differences ; Risk factors ; P450 ; CYP3A4 ; Acetaminophen ; Cyclophosphamide ; Ketoconazole ; Tamoxifen ; Human hepatocytes
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：255
- 期：Complete
- 页码：12-22
- 全文大小：746 K
文摘
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Hepatocytes from multiple individual differences exhibited vast differences in P450 activities.
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Hepatocyte lot with the highest CYP3A4 activity was found to be the most sensitive to hepatotoxic drugs.
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Results suggest that elevated P450 activity, especially CYP3A4, may be a risk factor for DILI.