Does maternal MDR1 C1236T polymorphism have an effect on placental arsenic levels?
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- 作者：Dilek Kaya-Akyü ; zlü ; ; kayadilek79@gmail.com" class="auth_mail" title="E-mail the corresponding author ; kaya@ankara.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Zeliha Kayaaltı ; Derya Doğan ; Tü ; lin Sö ; ylemezoğlu
- 关键词：Arsenic ; Phospho-glycoprotein (P-gp) ; Human multidrug resistance 1 (MDR1) ; MDR1 C1236T polymorphism ; Placental tissue
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：41
- 期：Complete
- 页码：142-146
- 全文大小：534 K
文摘
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This was the first study evaluating the effect of MDR1 C1236T polymorphism on placental arsenic levels.
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Placental arsenic levels of MDR1 C1236T variant mothers were found higher than those of wild type.
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Fetuses of mothers with TT genotype may be more susceptible to arsenic toxicity.