Effects of coffee consumption on gut recovery after surgery of gynecological cancer patients: a randomized controlled trial

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• 作者：Kemal G&uuml ; ngö ; rd&uuml ; k ; MD^a ; ^{drkemalgungorduk@gmail.com} ; İsa Aykut Ö ; zdemir ; MD^b ; Ö ; zg&uuml ; G&uuml ; ngö ; rd&uuml ; k ; MD^a ; Varol G&uuml ; lseren ; MD^c ; Mehmet Gokç ; &uuml ; MD^c ; Muzaffer Sancı ; MD^c
• 关键词：coffee consumption ; gynecologic cancer ; ileus
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：216
• 期：2
• 页码：145.e1-145.e7
• 全文大小：234 K
• 卷排序：216

文摘

Paralytic ileus that develops after elective surgery is a common and uncomfortable complication and is considered inevitable after an intraperitoneal operation.ObjectiveThe purpose of this study was to investigate whether coffee consumption accelerates the recovery of bowel function after complete staging surgery of gynecologic cancers.Study DesignIn this randomized controlled trial, 114 patients were allocated preoperatively to either postoperative coffee consumption with 3 times daily (n=58) or routine postoperative care without coffee consumption (n=56). Total abdominal hysterectomy and bilateral salpingo-oophorectomy with systematic pelvic and paraaortic lymphadenectomy were performed on all patients as part of complete staging surgery for endometrial, ovarian, cervical, or tubal cancer. The primary outcome measure was the time to the first passage of flatus after surgery. Secondary outcomes were the time to first defecation, time to first bowel movement, and time to tolerance of a solid diet.ResultsThe mean time to flatus (30.2±8.0 vs 40.2±12.1 hours; P<.001), mean time to defecation (43.1±9.4 vs 58.5±17.0 hours; P<.001), and mean time to the ability to tolerate food (3.4±1.2 vs 4.7±1.6 days; P<.001) were reduced significantly in patients who consumed coffee compared with control subjects. Mild ileus symptoms were observed in 17 patients (30.4%) in the control group compared with 6 patients (10.3%) in the coffee group (P=.01). Coffee consumption was well-tolerated and well-accepted by patients, and no intervention-related side-effects were observed.ConclusionCoffee consumption after total abdominal hysterectomy and systematic paraaortic lymphadenectomy expedites the time to bowel motility and the ability to tolerate food. This simple, cheap, and well-tolerated treatment should be added as an adjunct to the postoperative care of gynecologic oncology patients.