Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8+ T Cell Responses
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- 作者：Monica Loi1 ; Anne Mü ; ller1 ; Karin Steinbach2 ; Jennifer Niven2 ; 3 ; Rosa Barreira da Silva1 ; Petra Paul1 ; Laure-Anne Ligeon1 ; Assunta Caruso2 ; 3 ; Randy A. Albrecht4 ; 6 ; Andrea C. Becker7 ; Nicolas Annaheim1 ; Heike Nowag1 ; Jö ; rn Dengjel7 ; Adolfo Garcí ; a-Sastre4 ; 5 ; 6 ; Doron Merkler2 ; 8 ; Christian Mü ; nz1 ; 9 ; christian.muenz@uzh.ch" class="auth_mail" title="E-mail the corresponding author ; Monique Gannagé ; 1 ; 2 ; 3 ; 9 ; monique.ghannage@unige.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAK1 ; influenza ; LCMV ; endocytosis ; immune control
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：3 May 2016
- 年：2016
- 卷：15
- 期：5
- 页码：1076-1087
- 全文大小：2678 K
文摘
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Atg5- and 7-deficient dendritic cells (DCs) have increased surface MHC class I levels
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MHC class I internalization is compromised in the absence of Atg5
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In the absence of LC3 lipidation, AAK1 gets less efficiently recruited to MHC class I
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As a result, anti-viral CD8+ T cell responses are more efficiently stimulated