Bone shape difference between control and osteochondral defect groups of the ankle joint

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• 作者：N. Tü ; mer<sup>&dagger ; sup><sup> ; sup><sup>n.sarkalkan-1@tudelft.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; L. Blankevoort<sup>&Dagger ; sup><sup> ; sup><sup>l.blankevoort@amc.uva.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; M. van de Giessen<sup>&sect ; sup><sup> ; sup><sup>M.van_de_Giessen@lumc.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; M.P. Terra<sup>‖sup><sup> ; sup><sup>m.p.terra@amc.uva.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; P.A. de Jong<sup>¶ ; sup><sup> ; sup><sup>P.dejong-8@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; H. Weinans<sup>&dagger ; sup><sup> ; sup><sup>#sup><sup> ; sup><sup>&dagger ; &dagger ; sup><sup> ; sup><sup>h.h.weinans@tudelft.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; G.J.M. Tuijthof<sup>&dagger ; sup><sup> ; sup><sup>&Dagger ; sup><sup> ; sup><sup>g.j.m.tuijthof@tudelft.nl" class="auth_mail" title="E-mail the corresponding authorsup> ; A.A. Zadpoor<sup>&dagger ; sup><sup> ; sup><sup>a.a.zadpoor@tudelft.nl" class="auth_mail" title="E-mail the corresponding authorsup>
• 关键词：(Osteo)chondral defect ; Statistical shape model ; Tibia ; Talus ; Ankle ; Talocrural joint
• 刊名：Osteoarthritis and Cartilage
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：24
• 期：12
• 页码：2108-2115
• 全文大小：1830 K

文摘

The etiology of osteochondral defects (OCDs), for which the ankle (talocrural) joint is one of the common sites, is not yet fully understood. In this study, we hypothesized that bone shape plays a role in development of OCDs. Therefore, we quantitatively compared the morphology of the talus and the distal tibia between an OCD group and a control group.

sSec_2">Methods

spara0015">The shape variations of the talus and distal tibia were described separately by constructing two statistical shape models (SSMs) based on the segmentation of the bones from ankle computed tomography (CT) scans obtained from control (i.e., 35 CT scans) and OCD (i.e., 37 CT scans) groups. The first five modes of shape variation for the SSM corresponding to each bone were statistically compared between control and OCD groups using an analysis of variance (ANOVA) corrected with the Bonferroni for multiple comparisons.

sSec_3">Results

spara0020">The first five modes of variation in the SSMs respectively represented 49% and 40% of the total variance of talus and tibia. Less than 5% of the variance per mode was described by the higher modes. Mode 5 of the talus (<em>Pem> = 0.004) primarily describing changes in the vertical neck angle and Mode 1 of the tibia (<em>Pem> < 0.0001) representing variations at the medial malleolus, showed statistically significant difference between the control and OCD groups.

sSec_4">Conclusion

spara0025">Shape differences exist between control and OCD groups. This indicates that a geometry modulated biomechanical behavior of the talocrural joint may be a risk factor for OCD.