In聽vitro and in聽vivo evaluation of the antidiabetic activity of ursolic acid derivatives
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- 作者：Pan-Pan Wu wyuwpp@126.com" class="auth_mail ; Kun Zhang ; kzhang@gdut.edu.cn" class="auth_mail ; Yu-Jing Lu luyj@gdut.edu.cn" class="auth_mail ; Ping He hepingjyjy@sina.com" class="auth_mail ; Su-Qing Zhao ; sqzhao@gdut.edu.cn" class="auth_mail ; suqingz@hotmail.com" class="auth_mail
- 关键词：Ursolic acid derivatives ; Synthesis ; 伪-glucosidase inhibition ; Anti-diabetic
- 刊名：European Journal of Medicinal Chemistry
- 出版年：10 June 2014
- 年：2014
- 卷：80
- 期：Complete
- 页码：502-508
- 全文大小：974 K
文摘
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A series of ursolic acid derivatives were synthesized and spectrally characterized.
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Compounds class="boldFont">3–class="boldFont">5 and class="boldFont">8 are more potent in vitro than acarbose and UA.
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The kinetic study of compounds class="boldFont">3–class="boldFont">5 and class="boldFont">8 was carried out.
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Both compounds class="boldFont">3 and class="boldFont">4 have hypoglycemic effect in vivo.