Novel pseudorabies virus variant with defects in TK, gE and gI protects growing pigs against lethal challenge
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- 作者：Rui-Ming Hu ; Qing Zhou ; Wen-Bo Song ; Er-Chao Sun ; Mei-Mei Zhang ; Qi-Gai He ; Huan-Chun Chen ; Bin Wu ; wub@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zheng-Fei Liu ; lzf6789@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PRV variant ; Marker vaccine ; Growing pigs ; Safety ; Efficacy
- 刊名：Vaccine
- 出版年：2015
- 出版时间：26 October 2015
- 年：2015
- 卷：33
- 期：43
- 页码：5733-5740
- 全文大小：2485 K
文摘
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PRV variant with defect in TK, gE and gI (rSMX螖gI/gE螖TK) is safe for newborn piglets and sheep.
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rSMX螖gI/gE螖TK induced full protection in growing pigs against lethal challenge of PRV variant.
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Bartha-K61vaccine failed to confer full protection in growing pigs against lethal PRV variant challenge.
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rSMX螖gI/gE螖TK elicited higher neutralization antibody against PRV variant SMX than Bartha-K61 vaccine.
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PRV variant with defect in TK, gE and gI is a DIVA (differentiating infected from vaccinated animals vaccine) candidate.