Innocuity of a commercial live attenuated vaccine for epizootic hemorrhagic disease virus serotype 2 in late-term pregnant cows
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- 作者：Massimo Spedicato ; Irene Carmine ; Liana Teodori ; Alessandra Leone ; Ottavio Portanti ; Valeria Marini ; Maura Pisciella ; Alessio Lorusso ; a.lorusso@izs.it" class="auth_mail" title="E-mail the corresponding author ; Giovanni Savini
- 关键词：Epizootic hemorrhagic disease virus serotype 2 ; Pregnant cows ; Transplacental transmission ; Vaccine safety ; Live attenuated vaccines
- 刊名：Vaccine
- 出版年：2016
- 出版时间：14 March 2016
- 年：2016
- 卷：34
- 期：12
- 页码：1430-1435
- 全文大小：922 K
文摘
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The capability to cross the placental barrier is a well-known feature of some lab adapted, including vaccines, strains of Bluetongue virus.
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We tested the innocuity of the live attenuated vaccine strain used in Japan to control the virulent EHDV-2 Ibaraki virus.
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The vaccine has been shown to be immunogenic in vaccinees and it did not pass the placental barrier. Viremia in dams was absent and calves did show neither viral RNA nor infectious virus in the blood samples.
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The recent Ibaraki outbreak in Japan (2013) was not related to the spread of the vaccine strain in the environment.