Seven major genomic deletions of vaccinia virus Tiantan strain are sufficient to decrease pathogenicity
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- 作者：Yiquan Lia ; b ; Yuan Shenga ; b ; Yunjie Chua ; c ; Huifan Jia ; d ; Shuang Jianga ; b ; Tian Lana ; b ; Min Lia ; b ; Shuang Chena ; b ; Yuanyuan Fana ; b ; Wenjie Lia ; c ; Xiao Lia ; b ; lixiao06@mails.jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lili Suna ; e ; linjiaxiaoya@163.com" class="auth_mail" title="E-mail the corresponding author ; Ningyi Jina ; b ; e ; skylee6226@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Attenuated vaccinia virus vector ; Virulence ; Immunogenicity ; Tiantan strain
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：129
- 期：Complete
- 页码：1-12
- 全文大小：2347 K
文摘
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We construct an attenuated seven genes deficient vaccinia virus Tian Tan strain.
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Replication ability of the attenuated virus is not reduced.
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Cell toxicity of the attenuated virus is significantly decreased.
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The in vivo virulence of the attenuated virus is reduced.
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The attenuated virus is a candidate vector with increased safety.