Effects of a non-competitive N-methyl-d-aspartate (NMDA) antagonist, tiletamine, in adult zebrafish

详细信息    查看全文

• 作者：Tatiana O. Kolesnikova^a ; ¹ ; Sergey L. Khatsko^a ; ¹ ; Vadim A. Shevyrin^a ; ^b ; Yuri Yu Morzherin^a ; ^{yu.yu.morzherin@urfu.ru} ; Allan V. Kalueff^c ; ^{avkalueff@gmail.com}
• 关键词：Zebrafish ; Tiletamine ; Aquatic screening ; Sedative effects ; Central glutamatergic system ; Ketamine
• 刊名：Neurotoxicology and Teratology
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：62-67
• 全文大小：445 K
• 卷排序：59

文摘

Tiletamine is an NMDA receptor antagonist and a chemical analog of ketamine. CNS effects of tiletamine remain unclear, necessitating novel models and in-vivo screens. Zebrafish are a popular model organism for screening various neuroactive drugs. We investigated acute behavioral effects of 1, 5 and 10 mg/L of tiletamine on adult zebrafish. Tiletamine at 5 and 10 mg/L exerted robust dose-dependent sedative effects in zebrafish.