HLA haplotypes associated with type 1 diabetes mellitus in north indian children

详细信息    查看全文

• 作者：Kanga ; Uma ; Vaidyanathan ; Balu ; Jaini ; Ritika ; Menon ; Puthezath S. N. ; Mehra ; Narinder K.
• 关键词：HLA haplotypes ; residual pancreatic β ; -cell function ; thyroid autoantibodies ; type 1 diabetes mellitus
• 刊名：Human Immunology
• 出版年：2004
• 出版时间：January, 2004
• 年：2004
• 卷：65
• 期：1
• 页码：47-53
• 全文大小：186 K

文摘

Human leukocyte antigen (HLA) encoded susceptibility to develop type 1 diabetes mellitus (T1DM) has been investigated in children from North India. The results revealed significantly increased prevalence of HLA-A26, -B8, and -B50 among patients and strong positive association of the disease with DRB1*0301 (82.1 % vs 13.9 % , χ² = 71.3, odds ratio [OR] = 28.3) and a negative association with DRB1*02 (χ² = 12.2, PF = 38.5). HLA-DQB1*0201 occurred in 96.4 % of the patients, whereas the heterodimer DQA1*0501-DQB1*0201 was present in 82.1 % of patients (60.7 % in single dose and 21.4 % in double dose) and revealed significant deviation from the healthy controls (χ² = 74.1, p_c = 6.0E-10). In addition to DRB1*03, positive association was also observed with DRB1*09 (14.3 % vs 1.3 % , χ² = 13.4) and DRB1*04 (39.3 % vs 15.6 % , χ² = 8.39). No HLA association was observed in relation to residual pancreatic β-cell function or associated thyroid autoimmunity. Family analysis revealed involvement of multiple DR3+ve haplotypes with T1DM in North Indian children with A26-B8-DRB1*03 (25 % vs 3.5 % , χ² = 16.9, p = 3.96E-05) and Ax-B50-DRB1*03 (25 % vs 0.7 % , χ² = 44.7, p = 9.88E-11) being the most frequent haplotypes encountered among patients. The classical Caucasian haplotype A1-B8-DRB1*03 was infrequent (7.2 % ) among the diabetic children. The study highlights the race specificity of HLA association and disease associated HLA haplotypes in T1DM among North Indian Children.