New insights into the role of stromal cell-derived factor 1 (SDF-1/CXCL12) in the pathophysiology of multiple sclerosis
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- 作者：Hossein Khorramdelazada ; Vahid Bagheria ; Gholamhossein Hassanshahia ; Masoud Zeinalib ; Alireza Vakilianc ; d ; alirezavakilian7@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CXCL12 ; SDF-1 ; MS ; CXC chemokine ; Multiple sclerosis
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：290
- 期：Complete
- 页码：70-75
- 全文大小：419 K
文摘
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CXCL12/CXCR4/CXCR7 axis could act as a double-edged sword in the pathogenesis of MS.
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CXCL12 may induce CNS inflammatory response by leukocyte migration.
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Additionally, CXCL12 may contribute to remyelination and neuroprotection in MS.
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Potential therapeutic strategies may include preservation of CXCL12 level or the use of inhibitors.