Generation of m>5-HTb>2Cb>RYFPm> mouse line revealed 40% of hypothalamic POMC neurons co-express 5-HTb>2Cb>Rs in male and female mice.
m>Pomcm> expressed exclusively within 5-HTb>2Cb>R cells modulates energy intake and insulin sensitivity in male and female mice.
An unexpected sex difference in physical activity and energy expenditure is modulated by hypothalamic m>Pomcm>.
m>Pomcm> expressed exclusively within 5-HTb>2Cb>R cells differentially impacts body weight accumulation in male and female mice.
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