Incidence, age at onset, and potential reasons of malignant transformation in recurrent respiratory papillomatosis patients: 20 years experience

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• 作者：Gerein ; Valentin ; Rastorguev ; Eugen ; Gerein ; Johann ; Draf ; Wolfgang ; Schirren ; Joachim
• 刊名：Otolaryngology - Head and Neck Surgery
• 出版年：2005
• 出版时间：March, 2005
• 年：2005
• 卷：132
• 期：3
• 页码：392-394
• 全文大小：52.5 K

文摘

Forty-two patients with recurrent respiratory papillomatosis (RRP) were accepted into a multicenter prospective study in 1983 to 1990, treated with alfa-IFN 3 MU/m² 3 times a week and then followed-up until August 1, 2003. All the patients who had disease progression with pulmonary spread were characterized by insufficient response to IFN-therapy and detection of HPV type 11. Five patients (4/5 smokers) presented malignant transformation in lungs or nasopharynx (mean RRP duration was 27.2 ± 8 years from RRP onset and 14.6 ± 6.3 years from pulmonary spread until malignant transformation) with persistent RRP in larynx. The results of long-term follow-up in RRP patients with HPV 11 underline the necessity of reanalyzing the current therapy.