3¦Â-O-Glycosylated 16¦Â-acetoxy-9¦Â-H-lanosta-7,24-diene-3¦Â,18,20¦Â-triol, an intermediate metabolite from the sea cucumber Eupentacta fraudatrix and its biosynthetic significance
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- 作者：Alex ; ra S. Silchenko ; Anatoly I. Kalinovsky ; Sergey A. Avilov ; Pelageya V. Andryjashchenko ; Pavel S. Dmitrenok ; Vladimir I. Kalinin ; Valentin A. Stonik
- 关键词：Sea cucumbers ; Eupentacta fraudatrix ; 4 ; 4 ; 14-Trimethylsterol oligoglycosides ; Biosynthesis
- 刊名：Biochemical Systematics and Ecology
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：44
- 期：Complete
- 页码：53-60
- 全文大小：486 K
文摘
A novel oligoglycoside cucumarioside A8 with unprecedented hydroxy group at C-18 was isolated from sea cucumber Eupentacta fraudatrix and its structure elucidated. The presence of hydroxy group at C-18 indicates that the glycoside is a ¡°hot¡± metabolite that allows clarification of some peculiarities of 4,4,14-trimethylsterol glycoside biosynthetic pathways. A hypothetical scheme of biosynthesis of triterpene glycosides in sea cucumbers is proposed where direct formation of lanostane derivatives with a 7(8)-double bond from prosteroid cation is possible.