Bromine-containing alkaloids from the marine sponge Penares sp.

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• 作者：Ekaterina G. Lyakhova ; Sophia A. Kolesnikova ; Anatoly I. Kalinovsky ; Shamil Sh. Afiyatullov ; Sergey A. Dyshlovoy ; Vladimir B. Krasokhin ; Chau V. Minh ; Valentin A. Stonik
• 关键词：Marine alkaloids ; Sponge ; Penares sp. ; Carbazole ; Indolophenanthridine ; Tumor cells
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：7 November, 2012
• 年：2012
• 卷：53
• 期：45
• 页码：6119-6122
• 全文大小：392 K

文摘

Two new unusual alkaloids were isolated from the sponge Penares sp., collected from Viet Nam waters (the South China Sea). The structures of these compounds were established by analysis of 1D, 2D NMR (¹H-¹H COSY, DEPT, HSQC, HMBC, H2BC, and NOE), and MS data. Compound 1 shows moderate cytotoxicity against the human tumor cells HL-60 and HeLa.