Injury to the nervous system: A look into the ER
详细信息 查看全文
- 作者：Vicente Valenzuelaa ; b ; c ; Maritza Oñ ; atea ; b ; c ; d ; e ; Claudio Hetza ; b ; c ; f ; g ; chetz@med.uchile.cl" class="auth_mail" title="E-mail the corresponding author ; chetz@hsph.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; ; Felipe A. Courta ; d ; e ; felipe.court@umayor.cl" class="auth_mail" title="E-mail the corresponding author ;
- 关键词：ER stress ; Unfolded protein response ; Spinal cord injury ; Brain injury ; Peripheral nerve injury
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PB
- 页码：617-625
- 全文大小：422 K
文摘
- •
Injury to the central or peripheral nervous system still lacks an effective treatment.
- •
ER stress is emerging as a possible driver for neuronal dysfunction in nervous injury.
- •
Activation of the UPR can improve cognitive and motor recovery after injury.
- •
Therapeutic strategies to alleviate ER stress by modulating UPR are discussed.