A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement
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- 作者：Roberta La Starza ; Lucia Br ; imarte ; Valentina Pierini ; Valeria Nofrini ; Paolo Gorello ; Barbara Crescenzi ; Laura Berchicci ; Caterina Matteucci ; Silvia Romoli ; Donatella Beacci ; Roberto Rosati ; Massimo
- 刊名：Cancer Genetics and Cytogenetics
- 出版年：2009
- 出版时间：September 2009
- 年：2009
- 卷：193
- 期：2
- 页码：109-111
- 全文大小：97 K
文摘
We report a case of adult acute myeloid leukemia with a new t(11;12)(p15;q13) underlying a NUP98 rearrangement without HOXC cluster gene involvement. We designed a specific double-color double-fusion FISH assay to discriminate between this t(11;12)(p15;q13) and those producing NUP98-HOXC11 or NUP98-HOXC13. Our fluorescence in situ hybridization (FISH) showed that putative candidate partners mapping 600 kilobases centromeric to HOXC were RARG (retinoic acid receptor γ), MFSD5 (major facilitator superfamily domain containing 5), and ESPL1 (extra spindle pole bodies homolog 1). It is noteworthy that so far only ESPL1 has been implicated in human cancers. This FISH assay is useful for diagnostic screening of NUP98-positive leukemias.