5-(3′,4′-Dihydroxyphenyl)-γ-valerolactone and its sulphate conjugates, representative circulating metabolites of flavan-3-ols, exhibit anti-adhesive activity against uropathogenic Escherichia coli in bladder epithelial cells

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• 作者：Pedro Mena^a ; ¹ ; Dolores Gonzá ; lez de Llano^b ; ¹ ; Nicoletta Brindani^c ; Adelaida Esteban-Ferná ; ndez^b ; Claudio Curti^c ; Marí ; a Victoria Moreno-Arribas^b ; Daniele Del Rio^a ; ^{daniele.delrio@unipr.it} ; Begoñ ; a Bartolomé ; ^b ; ^{bartolome@ifi.csic.es}
• 关键词：Phenyl-γ-valerolactone ; Flavan-3-ol metabolite ; UPEC ; Peripheral metabolism ; Cranberry ; Urinary tract infections
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：275-280
• 全文大小：716 K
• 卷排序：29

文摘

Inhibition of adherence of UPEC to bladder cells by valerolactones was studied. Different concentrations of dihydroxyphenyl-valerolactone derivatives were tested. Differently sulphated dihydroxyphenyl-valerolactones showed anti-adhesive activity. Phenyl-valerolactones underwent extensive transformations due to cell metabolism. Prevention of urinary infections by cranberries may be mediated by valerolactones.