Novel Zebrafish EAE model: A quick in vivo screen for multiple sclerosis

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• 作者：Pushkar Kulkarni^a ; ^b ; ¹ ; ^{pushkark@drils.org} ; ^{kk.pushkar@gmail.com} ; Swapna Yellanki^b ; ¹ ; Raghavender Medishetti^b ; Dharmarajan Sriram^a ; Uday Saxena^b ; ^c ; Perumal Yogeeswari^a ; ^{pyogee@hyderabad.bits-pilani.ac.in} ; ^{pyogee.sriram@gmail.com}
• 关键词：Zebrafish ; Experimental autoimmune encephalomyelitis (EAE) ; Multiple Sclerosis (MS) ; Myelin oligodendrocyte glycoprotein (MOG) ; Fingolimod (Gilenya) ; Drug Discovery
• 刊名：Multiple Sclerosis and Related Disorders
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：11
• 期：Complete
• 页码：32-39
• 全文大小：1362 K
• 卷排序：11

文摘

We propose novel adult zebrafish EAE model for multiple sclerosis drugs screening. Disease induction in this model is by using myelin oligodendrocyte glycoprotein. The model has been validated using fingolimod hydrochloride (Gilenya). Further, detailed validation has been conducted with three known EAE modulators. It offers to be a quick simple protocol between in vitro and rodent studies.