High resolution transmission electron microscopy: A key tool to understand drug release from mesoporous matrices
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- 作者：Marina Martí ; nez-Carmonaa ; b ; d ; Montserrat Colillaa ; b ; d ; mcolilla@ucm.es" class="auth_mail" title="E-mail the corresponding author ; M. Luisa Ruiz-Gonzá ; lezc ; d ; José ; M. Gonzá ; lez-Calbetc ; d ; Marí ; a Vallet-Regí ; a ; b ; d ; vallet@ucm.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Silica-based mesoporous materials ; Functionalization ; Mesostructural order ; High resolution transmission electron microscopy ; Drug delivery
- 刊名：Microporous and Mesoporous Materials
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：225
- 期：Complete
- 页码：399-410
- 全文大小：2776 K
文摘
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Treating SBA15DPT with 12M HCl produces –PO3H2 groups but damages the mesostructure.
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HCl-SBA15DPT presents uncontrolled drug burst release compared with SBA15DPT.
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XRD and N2 adsorption are not enough to detect mesostructural damages in HCl-SBA15DPT.
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HRTEM is essential to understand drug release from mesoporous materials.