- 作者：Sebastiá ; n Manzanares Galá ; n ; smanzanares@sego.es ; Alicia Pineda Llorens ; M. Dolores Durá ; n Pé ; rez ; M. Setefilla Ló ; pez Criado ; José ; Luis Gallo Vallejo
- 关键词：Cribado prenatal ; Cribado del primer trimestre ; Cromosomopatí ; as ; Sí ; ndrome de Down ; Diagnó ; stico prenatal
- 刊名：Diagn¨®stico Prenatal
- 出版年：2013
- 出版时间：January-March, 2013
- 年：2013
- 卷：24
- 期：1
- 页码：3-10
- 全文大小：582 K
Introduction
There was no uniform policy for prenatal screening and diagnosis of chromosomal abnormalities in Spain until 2006. The Spanish Society of Obstetrics and Gynaecology (SEGO) recommends rejecting advanced maternal age as the only indication for invasive procedure, and proposes the first trimester combined test.
Objective
To determine the level of implementation of the SEGO recommendations and the changes in hospital screening practice in Spain.
Methods
A total of 54 Hospitals, that had attended to 149,320 pregnant women, and 53 hospitals with147,195 pregnancies, responded to an e-mail survey, in the year 2007 and 2011, respectively. The McNemar test was used to compare the results.
Results
A total 26 hospital centres performed invasive procedures for advanced maternal age only in 2007, and 11 in 2011 (P = .01); 31 had chorionic villus sampling (CVS) available in 2007, and 33 in 2011 (P=.005); in 42 implemented first trimester combined screening in 2007, and 50 in 2011 (p = ns); in 30 hospitals the only ultrasound marker was Nuchal translucency in 2007, and in 36 in 2011 (p = ns); 26 did not know the type of analyser used for determining biochemical markers in 2007, and 17 in 2011 (P<.01); and 34 the laboratory performed risk calculation in 2007 and 36 in 2011 (p = ns).
Conclusion
First trimester combined screening test is widely available across Spanish hospitals, and most centres, do not consider advanced maternal age as the only indication for the invasive procedure, have CVS available, perform combined first trimester test only with nuchal translucency as an ultrasound marker, do not know the analyser used for measure biochemical markers, and that the laboratory provide risk calculations.