文摘
We compared brain metabolite levels of BD patients and healthy controls using MRS. BD had elevated Glu, Gln, Gln/Glu, NAA, Cr& Cho in the ACC, Gln & Cho in the ltBG. These findings remained after participants of BD were limited to those with euthymia. Thus, activated glutamatergic neurotransmissionmay relate to BD’s pathophysiology. By removing the effects of Li and VPA, elevated Gln survived only in the ACC.