Cardiotoxicity in rabbits after long-term nandrolone decanoate administration
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- 作者：Fotini Vasilakia ; Christina Tsitsimpikoub ; Konstantinos Tsarouhasc ; Ioannis Germanakisd ; Marias Tzardie ; Matthaios Kavvalakisa ; Eren Ozcaglif ; Dimitrios Kouretasg ; Aristidis M. Tsatsakisa ; toxlab@med.uoc.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAS ; anabolic androgenic steroids ; TBARS ; thiobarbituric acid reactive species ; TAC ; total antioxidant capacity ; LDH ; lactate dehydrogenase ; CpK ; creatinine kinase ; BNP ; B-type natriuretic peptide ; PW ; pulsed wave Doppler ; TDI ; tissue Doppler imaging ; MPI ; myocardial performance index ; LV ; left ventricular
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：241
- 期：Complete
- 页码：143-151
- 全文大小：1886 K
文摘
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Cardiovascular effects of nandrolone decanoate on young rabbits.
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Focal fibrosis and inflammatory infiltrations of cardiac tissue in high dose groups.
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Preserved systolic performance, distorted MPI values, diastolic impairment.
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TBARS increased in high dose groups, troponin increased in wash-out period.
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Heart tissue relative telomerase activity increased dose-dependently.