Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins
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- 作者：Kamila Skieterskaa ; kamila.skieterska@ugent.be" class="auth_mail" title="E-mail the corresponding author ; Ao Shenb ; aoshen@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author ; Dorien Clarissea ; 1 ; dorien.clarisse@ugent.be" class="auth_mail" title="E-mail the corresponding author ; Pieter Rondoua ; 2 ; pieter.rondou@ugent.be" class="auth_mail" title="E-mail the corresponding author ; Dasiel Oscar Borroto-Escuelac ; dasiel.borroto.escuela@ki.se" class="auth_mail" title="E-mail the corresponding author ; Bé ; atrice Lintermansa ; 2 ; beatrice.lintermans@ugent.be" class="auth_mail" title="E-mail the corresponding author ; Kjell Fuxec ; kjell.fuxe@ki.se" class="auth_mail" title="E-mail the corresponding author ; Yang Kevin Xiangb ; ykxiang@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author ; Kathleen Van Craenenbroecka ; kathleen.vancraenenbroeck@ugent.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：GPCR ; β-arrestin ; KLHL12 ; ubiquitination ; dopamine D4 receptor
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：28
- 期：8
- 页码：1001-1014
- 全文大小：2258 K
文摘
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D4R, KLHL12 and β-arrestin 2 exist in a single protein complex
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β-arrestins are not required for the KLHL12-mediated D4R ubiquitination
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No influence of KLHL12 on D4R internalization or MAPK phosphorylation was observed
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Cullin3 also interacts with β-arrestins but has no influence on their ubiquitination