Parametric imaging and quantitative analysis of the PET amyloid ligand [18F]flutemetamol
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- 作者：Kerstin Heurlinga ; Kerstin.Heurling@radiol.uu.se" class="auth_mail" title="E-mail the corresponding author ; Chris Buckleyb ; Koen Van Laerec ; Rik Vandenberghed ; Mark Lubberinka ; e
- 关键词：PET ; Amyloid imaging ; [18F]flutemetamol ; Parametric imaging
- 刊名：NeuroImage
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：121
- 期：Complete
- 页码：184-192
- 全文大小：1421 K
文摘
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We investigate the application of parametric images methods for [18F]flutemetamol.
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We validate kinetics models for [18F]flutemetamol using simulations.
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Simulations showed the highest precision and accuracy for SUVR and reference Logan.
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Pre-filtered MRTM2 works best for creation of [18F]flutemetamol parametric images.
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SUVR images have almost equally high correlation with kinetic modeling as MRTM2.