Cholinergic depletion and basal forebrain volume in primary progressive aphasia

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• 作者：Jolien Schaeverbeke^a ; ^b ; ^c ; Charlotte Evenepoel^a ; ^b ; ^c ; Rose Bruffaerts^a ; ^d ; Koen Van Laere^c ; ^e ; Guy Bormans^e ; ^g ; Eva Dries^d ; Thomas Tousseyn^h ; Natalie Nelissen^a ; ^j ; Ronald Peetersⁱ ; Mathieu Vandenbulcke^b ; ^f ; Patrick Dupont^a ; ^b ; ^c ; Rik Vandenberghe^a ; ^b ; ^c ; ^d ; ^{rik.vandenberghe@uzleuven.be}
• 关键词：Kinetic modeling ; Basal forebrain ; Acetylcholinesterase ; N-[11C]-Methylpiperidin-4-yl propionate ; PET ; Primary progressive aphasia
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：271-279
• 全文大小：1159 K
• 卷排序：13

文摘

Using PET we examined cholinesterase activity in PPA. Cholinergic depletion occurred in the logopenic variant. Basal forebrain atrophy mainly occurred in the semantic variant. Cholinergic depletion did not correlate with basal forebrain atrophy. Unexpectedly, semantic variant was associated with cholinergic activity increases.