The role of IS26 in evolution of a derivative of the virulence plasmid of Salmonella enterica serovar Enteritidis which confers multiple drug resistance

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• 作者：Vanesa Garc&iacute ; a^a ; ¹ ; Patricia Garc&iacute ; a^a ; ² ; Irene Rodr&iacute ; guez^a ; Rosaura Rodicio^b ; M. Rosario Rodicio^a ; ^{rrodicio@uniovi.es}
• 关键词：Virulence plasmid ; Plasmid evolution ; IS26 ; Multidrug resistance ; S. Enteritidis
• 刊名：Infection, Genetics and Evolution
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：45
• 期：Complete
• 页码：246-249
• 全文大小：490 K
• 卷排序：45

文摘

A pSEV derivative containing multiple resistance genes was sequenced and annotated IS26, with 14 copies, has played a key role in the evolution of the plasmid Major inversions and small deletions have altered the pSEV backbone The resistance genes are clustered in two distinct regions both flanked by IS26 and carrying internal copies of the same IS According to the intrinsic instability of pUO-SeVR1, further rearrangements are expected