A novel DNA biosensor to detect the rs4839469 locus of vangl1 gene for dysontogenesis prediction has been developed for the first time.
PPy/streptavidin, which as modified matrix material, and Au-PAMAM-CP nanocomposite probe, a novel probe, were used for the rs4839469 locus of vangl1 gene detection.
Wide linear range, good specificity and high sensitivity of the sensor have been achieved.