Death-inducing functions of ligands of the tumor necrosis factor family: a Sanhedrin verdict
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- 作者：Wallach ; David ; Kovalenko ; Andrew V ; Varfolomeev ; Eugene E ; Boldin ; Mark P
- 关键词：BIR Baculovirus inhibitor of death ; DD death domain ; ER endoplasmic reticulum ; LT lymphotoxin ; NGF nerve growth factor ; TNF tumor necrosis factor
- 刊名：Current Opinion in Immunology
- 出版年：1998
- 出版时间：June, 1998
- 年：1998
- 卷：10
- 期：3
- 页码：279-288
- 全文大小：989 K
文摘
Members of the tumor necrosis factor ligand family can kill cells in a rather straightforward manner. They induce their receptors to recruit and activate caspases, enzymes that are critically involved in the death process, and this activation is further amplified by intracellular mitochondria-associated mechanisms. The potentially hazardous expression of the ligands occurs widely in the body; it is antigen-restricted only in the lymphocytes. Yet, in addition to control modes affecting ligand expression, there are numerous inhibitory mechanisms that act within target cells, to make doubly sure of avoiding an undue ‘death verdict’, while allowing the cells to exhibit other, noncytocidal effects of the ligands.