Effect of glucose variability on pathways associated with glucotoxicity in diabetes: Evaluation of a novel in vitro experimental approach
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- 作者：Katarí ; na Kuricová ; a ; Luká ; &scaron ; Pá ; cala ; Jan &Scaron ; oupalb ; Martin Prá ; zný ; b ; mpra@lf1.cuni.cz" class="auth_mail" title="E-mail the corresponding author ; Kateřina Kaňková ; a
- 关键词：Glycaemic variability ; Continuous glucose monitoring ; Diabetes complications ; Hyperglycaemia ; Hypoglycaemia ; Pentose phosphate pathway
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：114
- 期：Complete
- 页码：1-8
- 全文大小：1109 K
文摘
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A new in vitro experimental approach to the research of glucose variability is presented.
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Data from continual glucose monitoring system were used to construct different glucose profiles.
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Glycaemic variability may have similar or even greater effect than continuous hyperglycaemia on the expression of several genes relevant to pathogenesis of diabetes microvascular complications.