Robust Asymmetric Localization of Planar Polarity Proteins Is Associated with Organization into Signalosome-like Domains of Variable Stoichiometry

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• 作者：Helen Strutt¹ ; ² ; Jessica Gamage¹ ; ² ; David Strutt¹ ; ³ ; ^{d.strutt@sheffield.ac.uk}
• 关键词：signaling ; polarity ; planar polarity ; PCP ; frizzled ; stoichiometry
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：6 December 2016
• 年：2016
• 卷：17
• 期：10
• 页码：2660-2671
• 全文大小：4013 K
• 卷排序：17

文摘

Planar polarity proteins form signalosome-like complexes of variable stoichiometry Flamingo and Frizzled form a stoichiometric nucleus within the complex Asymmetric localization of core proteins is robust to changes in complex composition Core protein stability in complexes is not dependent on complex stoichiometry